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COMPLEMENT C9
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DeCS
Descriptor
English
:
Complement C9
Descriptor
Spanish
:
complemento C9
Descriptor
Portuguese
:
Complemento C9
Synonyms
English
:
C9 Complement
C9, Complement
Complement 9
Complement Component 9
Complement, C9
Component 9, Complement
Tree Number:
D12.776.124.486.274.850
Definition
English
:
A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the
polymerization
of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell.
Patients
with C9 deficiency suffer from recurrent
bacterial infections.
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22140
Unique Identifier:
D003186
Occurrence in VHL
:
Similar:
DeCS